Originally there was a city gate near here and the proximity to St James Church combined to give the street its name. Now best known for being the home of the world famous Guinness Brewery which was founded in 1759. The brewery now covers over 64 acres in the area and is one of the largest in the world.
| Building | Architect | Date |
| - | Samuel Geoghegan | Grand Canal Harbour |
| 1876-82 | Samuel Geoghegan | Hop Store |
| 1880s | George Wilkinson | Offices |
| 1886-6 | Robert Worthington | Malt Stores |
| - | - | Guinness Gate Lodge |
| 1903-4 / 2001 | A.H. Hignett / RKD Architects | Storehouse |
| - | - | Power Station |